Coxibs: Can this Class of Drugs Survive?
نویسنده
چکیده
منابع مشابه
C oxibs : The new super aspirins or unsafe pain k illers ? Educational Forum
The new generation of analgesics and antiinflammatory drugs, namely, the selective inhibitors of cyclooxygenase–2 (COX-2) enzymes, popularly known as Coxibs, have become a very popular class of drugs because of their gastro-sparing property. Coxibs were the widely prescribed drugs (nearly 8 million people round the globe take these drugs) until the recent setback with rofecoxib, which was withd...
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The selective COX-2 inhibitors (coxibs) were originally developed to minimise the adverse effects of conventional non-steroidal anti-inflammatory drugs (NSAIDs) while maintaining the same analgesic and anti-inflammatory properties. Many large studies confirmed the improved gastric side effect profile of coxibs compared with non-selective NSAIDs; however, reports of increased cardiovascular morb...
متن کاملA Growing Class of Anti-Inflammatory Drugs
For about two years, selective inhibitors of cyclooxygenase-2 have been hailed as powerful additions to the armamentarium of nonsteroidal anti-inflammatory drugs (NSAIDs). Predicted by financial analysts to become among the pharmaceutical industry's greatest-ever blockbusters, two so-called coxibs are now widely utilized clinically: rofecoxib (Vioxx, Merck) and celecoxib (Celebrex, Monsanto). T...
متن کامل1. The effects of COX-2 anti-inflammatory drugs on soft tissue healing: a review of the literature
COX-2 specific inhibitors (coxibs) have become a popular treatment for musculoskeletal disorders given that the incidence of gastrointestinal side effects is lower with these drugs than with traditional non-steroidal anti-inflammatory drugs. The aim of this review is to discuss the results of animal studies investigating the role of coxibs in the healing of soft tissues. MEDLINE was searched (y...
متن کاملCardiovascular Effects of COX-2 Inhibitors: A Review of the Literature
When cyclooxygenase-2 (COX-2) inhibitors (coxibs) came on the market, they were expected to provide a treatment alternative to nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) for patients who were at risk for gastrointestinal (GI) complications. For more than five years, coxibs have been prescribed to millions of patients for the treatment of arthritis, acute pain, Alzheimer’s diseas...
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عنوان ژورنال:
- Vascular Health and Risk Management
دوره 1 شماره
صفحات -
تاریخ انتشار 2005